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KMID : 0371319960500060962
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Journal of the Korean Surgical Society
1996 Volume.50 No. 6 p.962 ~ p.967
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Usefulness of Carcinoembryonic Antigen Measurement in Peritoneal Washings in Patients with Colorectal Cancer
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Abstract
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The majority of patients who die of recurrent colorectal cancer have local disease such as peritoneal carcinomatosis and recurrence at the resection site. Peritoneal recurrence after curative resection of malignant tumor is considered to be
caused
by
microscopic dissemination of cancer cells from the primary tumor which invaded serosal surfaces. The prediction of peritoneal carcinomatosis as a site of treatment failure can not be defined accurately by the routine clinical studies. Cytology
examination of peritoneal washings has been used. However. the results of cytologic study depend on the technique and ability of the cytologist. In this study, in order to predict peritoneal carcinomatosis, we measured carcinoembryonic antigen
CEA
levels of peritoneal washings(mean: 7.58ng/ml and rates greater than 5ng/ml: 46.7%) were the same as those of serum (8.04ng/ml, 50%). CEA levels above 5ng/ml in peritoneal washing were found in 4 out of 15 patients(26.7%) with serum levels less
than
5ng/ml and 10 out of 15 patients(66.75) with levels greater than 5ng/ml in the serum, and in none of 2 patients(0%) with no serosal invasion and 14 out of 28 patients(50%) with serosal invasion, and in 13 out of 21 patients(61.9%) with colon and
upper
rectal cancer and 1 out of 9 patients(11.1%) with lower rectal cancer. Lymph node involvement didn't affect the elevation of CEA level. Results thus far show that CEA levels in peritoneal washings were influenced by the serum CEA level, serosal
invasion
and location of mass. In addition, CEA levels in peritoneal washings may be used as a indicator of peritoneal carcinomatosis in patients with colon cancer.
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KEYWORD
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